The synapse in schizophrenia: molecular impacts of genetic variation

Project Code

MRCNMH24Ex Clifton

Research Theme

Neuroscience and Mental Health

Full Project Description

Please download the below document for a full project description and to see the full supervisory team.


To improve treatments for schizophrenia there is a need to better understand the biology impacted by genetic mutations conferring risk to the disorder. This project will aim to investigate the effects of high-risk genetic variants on synapses and their molecular constituents. We will make use of cell-specific RNA sequencing and large-scale patient genomic data to quantify these effects and predict biological vulnerability in the brain.

Lead Supervisor

Dr Nicholas Clifton

Lead Supervisor Email

University Affiliation