Project Code
MRCIIAR26Ca Fraser
Project Type
Wet lab
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
How does Wnt signalling determine tissue repair versus scarring following Acute Kidney Injury (AKI)? AKI is very common. Some people recover fully, but others suffer kidney failure. The Wnt pathway is crucial in kidney development, and we have shown experimentally that AKI can be improved by controlled stimulation of Wnt signalling. You will evaluate the effects of Wnt activation in established AKI models, using state-of-the-art single cell RNA sequencing and spatial transcriptomic analyses to provide an unparalleled level of detail. This will help you to identify potential targets for clinical validation that you will test experimentally.
Lead Supervisor
Professor Donald Fraser
Lead Supervisor Email
University Affiliation
Cardiff