Project Code
MRCNMH26Ca Smith
Project Type
Wet lab
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
Huntington’s disease (HD) is a fatal inherited brain disorder with no effective treatment. It causes specific neurons in the brain to degenerate, leading to involuntary movements, cognitive decline and sleep disturbances. This PhD project aims to uncover how these neurons die by combining advanced tools in Drosophila genetics, human iPSC-derived neurons and metabolomics. The student will also screen potential therapeutic compounds in HD models. This is a unique opportunity to work across model systems and technologies to understand disease mechanisms and explore new treatment strategies.
Lead Supervisor
Dr Gaynor Smith
Lead Supervisor Email
University Affiliation
Cardiff