Project Code
MRCIIAR25Ca Fielding
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
Human cytomegalovirus (HCMV) is the leading infectious cause of congenital birth defects and causes severe disease immunosuppressed individuals. Immune cells, such as T-cell and Natural killer (NK) cells, are important for the control of cytomegalovirus infection, but the virus employs many immune evasion strategies. Some target cellular inhibitory receptors to inhibit these immune cells. This project aims to increase our understanding of HCMV’s interaction with the immune system and how it targets inhibitory receptors expressed by natural killer cells and T-cells to allow immune evasion suggesting future therapeutic avenues. The student will receive cutting-edge training in virology and immunology
Lead Supervisor
Dr Ceri Fielding
Lead Supervisor Email
fieldingCA@cardiff.ac.uk
University Affiliation
Cardiff