Enhancing Immunological Control of SARS-CoV-2

Project Code

MRCIIAR25Ca Stanton

Research Theme

Infection, Immunity, Antimicrobial Resistance and Repair

Project Summary Download

Summary

Neutralizing antibodies are key to preventing transmission of SARS-CoV-2, however the virus can rapidly mutate to avoid these. Furthermore, once infected, neutralizing antibodies cannot access intracellular virus. Therefore, antibodies that recognise cell-associated virus are critical. However, current vaccines fail to induce these. We will investigate how this activity can be induced, as the basis for next-generation and variant-resistant coronavirus vaccines.

Lead Supervisor

Professor Richard Stanton

Lead Supervisor Email

stantonrj@cardiff.ac.uk

University Affiliation

Cardiff