Project Code
MRCNMH25Ca Smith
Research Theme
Neuroscience & Mental Health
Project Summary Download
Summary
Huntington’s disease (HD) is an inherited disorder that causes specific neurons in the brain to die. HD patients develop uncontrollable movements as well as cognitive and sleep problems, and there is currently no effective treatment. In order to develop therapies, we need to understand the mechanism of how these neurons are lost. To help answer this, the PhD student will be trained in: Drosophila (fruit fly) genetics, human iPSC-derived neuron cultures and big data driven Metabolomic analysis. The PhD student will also test whether several drugs can alleviate hallmark disease features in models of HD.
Lead Supervisor
Dr Gaynor Ann Smith
Lead Supervisor Email
Smithga@cardiff.ac.uk
University Affiliation
Cardiff