Project Code
MRCNMH25Ex Gold
Research Theme
Neuroscience & Mental Health
Project Summary Download
Summary
Mitochondria provide energy essential for life and are dependent on the delivery of proteins from the cytosol for their biogenesis, maintenance and regeneration. Defects in protein import affect cellular bioenergetics and thereby cause muscular, neurological and age-related degenerative diseases. In this project, the effects of defective protein import will be studied at both the cellular and protein structure level using state-of-the-art methodologies including CRISPR-based genome editing of human cells for cryo-electron microscopy. The results will boost understanding of how mitochondrial protein import is essential for mitochondrial homeostasis and health, and how import failure relates to disease.
Lead Supervisor
Dr Vicki Gold
Lead Supervisor Email
v.a.m.gold@exeter.ac.uk
University Affiliation
Exeter