Genetic predisposition to accelerated ageing: targeting telomeres using sex hormone supplementation in Idiopathic Pulmonary Fibrosis

Project Code

MRCPHS24Ex Scotton

Research Theme

Population Health Sciences

Full Project Description

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Lung fibrosis is a devastating disease which causes 1% of UK deaths. On average, patients only survive 2-3 years after diagnosis. Ageing is a big risk factor; patients often have unusually short telomeres, correlating with a reduction in sex hormone levels. We will investigate if boosting hormone levels might improve telomere length and reduce disease burden – using data from cutting-edge lab experiments with lung cells, combined with analyses of patient genetics.

Lead Supervisor

Professor Chris Scotton

Lead Supervisor Email

University Affiliation