How does the schizophrenia candidate gene Sp4 influences transcription during neurodevelopment?

Project Code

MRCNMH24Ca Isles

Research Theme

Neuroscience and Mental Health

Full Project Description

Please download the below document for a full project description and to see the full supervisory team.


Both common and rare variants in the gene encoding the neuronal transcription factor Sp4 have been linked to schizophrenia. This project explores how those variants alter the ability of Sp4 to regulate the activity of the genome. The student will gain a range of sophisticated in vivo, molecular biology, and bioinformatic techniques and apply these in order unravel the biology that links Sp4 to brain function, and identify what goes wrong in schizophrenia.

Lead Supervisor

Professor Anthony Isles

Lead Supervisor Email

University Affiliation