Neuroscience and Mental Health
Full Project Description
Please download the below document for a full project description and to see the full supervisory team.
Both common and rare variants in the gene encoding the neuronal transcription factor Sp4 have been linked to schizophrenia. This project explores how those variants alter the ability of Sp4 to regulate the activity of the genome. The student will gain a range of sophisticated in vivo, molecular biology, and bioinformatic techniques and apply these in order unravel the biology that links Sp4 to brain function, and identify what goes wrong in schizophrenia.
Professor Anthony Isles
Lead Supervisor Email