Neuroscience and Mental Health
Full Project Description
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Genetic risk factors for psychiatric disorders are clustered around genes that regulate synaptic function and adaptation, indicating common disrupted biological processes. We have revealed how one of these genes (Dlg2) perturbs a core feature of synaptic signalling. In this project, we will uncover how this leads to abnormal cognition by directly measuring neuronal adaptations during tasks demanding cognitive flexibility, and test mechanisms to rescue cognition.
Professor Jack Mellor
Lead Supervisor Email