Overcoming β-lactamase-mediated antibiotic resistance by combining biomolecular simulation and experiment

Project Code

MRCIIAR24Br Van der Kamp

Research Theme

Infection, Immunity, Antimicrobial Resistance and Repair

Full Project Description

Please download the below document for a full project description and to see the full supervisory team.


Antibiotic resistance threatens human health. β-lactamases cause resistance to β-lactams, the most widely used antibiotics. Class C β-lactamases are not well understood, but variants are emerging that help bacteria evade even ‘last resort’ treatments. Combining computer simulation and experimental methods can explain how, guiding us to regain the upper hand in the ‘biochemical warfare’ between humans and bacteria.

Lead Supervisor

Dr Marc Van der Kamp

Lead Supervisor Email


University Affiliation