Project Code MRCIIAR26Br Shytaj Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Human T-lymphotropic virus 1 (HTLV-1) causes lifelong infections and can lead to severe diseases like adult T-cell leukaemia/lymphoma (ATL), with…
Overcoming β-lactamase-mediated antibiotic resistance by combining biomolecular simulation and experiment
Project Code MRCIIAR26Br Van der Kamp Project Type The project will be a combination of dry and wet; with a focus on dry-lab (computational) activities, but wet-lab based activities are also a key component (enzyme production & purification, enzyme kinetics,…
Systematic investigation of the interaction of human cytomegalovirus with the immune system
Project Code MRCIIAR26Ca Fielding Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Human cytomegalovirus (HCMV) is a herpesvirus that causes significant disease in individuals with impaired immune control. HCMV causes significant morbidity…
Understanding the dual roles of Wnt signalling in kidney injury, inflammation and repair following acute kidney injury
Project Code MRCIIAR26Ca Fraser Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary How does Wnt signalling determine tissue repair versus scarring following Acute Kidney Injury (AKI)? AKI is very common. Some people…
Immune modulation of tonsillar Natural Killer cell immunity by Group A Streptococcus
Project Code MRCIIAR26Ca McLaren Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary The human tonsils are crucial for producing neutralizing antibodies against infection yet are a breeding ground for Group A Streptococcus…
Developing precision guided, viral based therapies using machine learning approaches
Project Code MRCIIAR26Ca Parker Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary The Viral ImmunoTherapies and Advanced Therapeutics Laboratory engineers “smart viruses” for targeted treatment of cancer and genetic diseases. These viruses…
Sweet disposition: combatting bacterial infections and antimicrobial resistance with designer proteins that target biofilm matrix carbohydrates
Project Code MRCIIAR26Ca Parmeggiani Project Type The project combines dry- and wet-lab elements but aligns more closely with a wet-lab based project considering the costs needed to deliver the work. Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary…
Identification of novel antifungals: Synthesis, structure-activity correlation, and antifungal activity of novel molecular scaffolds from repurposable drugs
Project Code MRCIIAR26Ca Pertusati Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Fungal infections are a major threat to public health as they are becoming increasingly resistant to treatment. Only four classes…
Can Damage Associated Molecular Patterns be targeted to reduce susceptibility to infections in people with Chronic Kidney Disease?
Project Code MRCIIAR26Ca Raby Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary People with chronic kidney disease (CKD) are more vulnerable to infections, in part because their immune systems don’t function properly.…
Stop “Superbugs” to fight antimicrobial resistance
Project Code MRCIIAR26Ca Serpi Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary While antibiotics have revolutionised the landscape of medicine saving millions of lives, their misuse has also resulted in the rise…