Project Code MRCIIAR26Br Mann Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary This project addresses the ongoing challenge posed by HIV-1, a virus infecting approximately 38 million people globally, with Subtype C…
Exploring Communication Networks in DNA Gyrase: A Pathway to Next-Generation Antibiotic Discovery
Project Code MRCIIAR26Br Oliveira Project Type This is a computational led project using biomolecular simulations, but will include laboratory experiments to test/validate predictions arising from the simulations. Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Bacterial…
Elucidating genetic and immune signatures of severe dengue
Project Code MRCIIAR26Br Rivino Project Type This project is cross-disciplinary and includes both wet and dry lab work (approx 60% wet lab and 40% dry lab). Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Dengue is…
Targeting Antioxidant Metabolic Pathways in HTLV-1 Associated Adult T-Cell Leukemia
Project Code MRCIIAR26Br Shytaj Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Human T-lymphotropic virus 1 (HTLV-1) causes lifelong infections and can lead to severe diseases like adult T-cell leukaemia/lymphoma (ATL), with…
Overcoming β-lactamase-mediated antibiotic resistance by combining biomolecular simulation and experiment
Project Code MRCIIAR26Br Van der Kamp Project Type The project will be a combination of dry and wet; with a focus on dry-lab (computational) activities, but wet-lab based activities are also a key component (enzyme production & purification, enzyme kinetics,…
Systematic investigation of the interaction of human cytomegalovirus with the immune system
Project Code MRCIIAR26Ca Fielding Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Human cytomegalovirus (HCMV) is a herpesvirus that causes significant disease in individuals with impaired immune control. HCMV causes significant morbidity…
Understanding the dual roles of Wnt signalling in kidney injury, inflammation and repair following acute kidney injury
Project Code MRCIIAR26Ca Fraser Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary How does Wnt signalling determine tissue repair versus scarring following Acute Kidney Injury (AKI)? AKI is very common. Some people…
Immune modulation of tonsillar Natural Killer cell immunity by Group A Streptococcus
Project Code MRCIIAR26Ca McLaren Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary The human tonsils are crucial for producing neutralizing antibodies against infection yet are a breeding ground for Group A Streptococcus…
Developing precision guided, viral based therapies using machine learning approaches
Project Code MRCIIAR26Ca Parker Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary The Viral ImmunoTherapies and Advanced Therapeutics Laboratory engineers “smart viruses” for targeted treatment of cancer and genetic diseases. These viruses…
Sweet disposition: combatting bacterial infections and antimicrobial resistance with designer proteins that target biofilm matrix carbohydrates
Project Code MRCIIAR26Ca Parmeggiani Project Type The project combines dry- and wet-lab elements but aligns more closely with a wet-lab based project considering the costs needed to deliver the work. Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary…