Project Code
MRCPHS25Ca Jurkowska
Research Theme
Population Health Sciences
Project Summary Download
Summary
What most of us do naturally and take for granted – the breathing – 500 million people struggle with as they suffer from incurable lung disease. Epigenetic mechanisms control what genes are switched on or off. They get dysregulated by environmental exposures, causing disease. Despite the identification of epigenetic changes in lung diseases, their functional role remains unknown.
This project will establish an exciting new technology called epigenetic editing to precisely manipulate epigenetic signals in lung cells. It will probe which epigenetic changes drive disease phenotypes and if their correction will boost cell regeneration, accelerating the discovery of novel treatments.
Lead Supervisor
Dr Renata Jurkowska
Lead Supervisor Email
jurkowskar@cardiff.ac.uk
University Affiliation
Cardiff