Project Code
MRCNMH24Br Wilkinson
Research Theme
Neuroscience and Mental Health
Full Project Description
Please download the below document for a full project description and to see the full supervisory team.
Summary
Mutations in the TSC1 gene lead to Tuberous Sclerosis (TS), a genetic disorder associated with severe neurological symptoms. However, how mutations in TSC1 affect the brain is not well understood. Using a range of cell culture and in vivo techniques, we will examine how deleting TSC1, or replacing it with mutant versions that cause TS, affect the health and function of neurons. The findings will help inform the future treatment of patients with TS.
Lead Supervisor
Dr Kevin Wilkinson
Lead Supervisor Email
kevin.wilkinson@bristol.ac.uk
University Affiliation
Bristol