Understanding neuronal dysfunction in Tuberous Sclerosis

Project Code

MRCNMH24Br Wilkinson

Research Theme

Neuroscience and Mental Health

Full Project Description

Please download the below document for a full project description and to see the full supervisory team.


Mutations in the TSC1 gene lead to Tuberous Sclerosis (TS), a genetic disorder associated with severe neurological symptoms. However, how mutations in TSC1 affect the brain is not well understood. Using a range of cell culture and in vivo techniques, we will examine how deleting TSC1, or replacing it with mutant versions that cause TS, affect the health and function of neurons. The findings will help inform the future treatment of patients with TS.

Lead Supervisor

Dr Kevin Wilkinson

Lead Supervisor Email


University Affiliation