Neuroscience and Mental Health
Full Project Description
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Mutations in the TSC1 gene lead to Tuberous Sclerosis (TS), a genetic disorder associated with severe neurological symptoms. However, how mutations in TSC1 affect the brain is not well understood. Using a range of cell culture and in vivo techniques, we will examine how deleting TSC1, or replacing it with mutant versions that cause TS, affect the health and function of neurons. The findings will help inform the future treatment of patients with TS.
Dr Kevin Wilkinson
Lead Supervisor Email