Project Code
MRCIIAR24Ex Scholpp
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Full Project Description
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Summary
Cells communicate with a language of chemical signals to orchestrate cell behaviour at a distance. We have shown that signalling protrusions, namely cytonemes, transport Wnt signals, between distant cells. In gastric cancer, we observed an increased cytoneme network directly linked to tumour growth. This project will use cancer cell assays and xenograft technology to study the importance of cytoneme-mediated, paracrine Wnt signalling transport in 3D.
Lead Supervisor
Professor Steffen Scholpp
Lead Supervisor Email
s.scholpp@exeter.ac.uk
University Affiliation
Exeter