Infection, Immunity, Antimicrobial Resistance and Repair
Full Project Description
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Type 1 diabetes is a complex disease caused by the loss of insulin-producing cells. Gut microbe changes and a weakened gut barrier are observed in those who develop T1D. We propose that genetic predisposition disrupts immune tolerance, affecting the gut barrier, promoting the development of harmful cells. The PhD aims to study the gut immune system in rare T1D donor tissue, alongside murine tissue to develop targeted treatments to protect insulin-producing cells.
Professor Sarah Richardson
Lead Supervisor Email