The crosstalk between the duodenum and the pancreas: Profiling the immune system to identify the role of the gut in the pathogenesis of type 1 diabetes

Project Code

MRCIIAR24Ex Richardson

Research Theme

Infection, Immunity, Antimicrobial Resistance and Repair

Full Project Description

Please download the below document for a full project description and to see the full supervisory team.


Type 1 diabetes is a complex disease caused by the loss of insulin-producing cells. Gut microbe changes and a weakened gut barrier are observed in those who develop T1D. We propose that genetic predisposition disrupts immune tolerance, affecting the gut barrier, promoting the development of harmful cells. The PhD aims to study the gut immune system in rare T1D donor tissue, alongside murine tissue to develop targeted treatments to protect insulin-producing cells.

Lead Supervisor

Professor Sarah Richardson

Lead Supervisor Email

University Affiliation