AI and structure based drug discovery of chaperones for misfolded lysosomal enzymes involved in neurodegenerative disease

Project Code

MRCNMH24Ca Lloyd-Evans

Research Theme

Neuroscience and Mental Health

Full Project Description

Please download the below document for a full project description and to see the full supervisory team.


A major risk gene for Parkinson disease encodes a mis-folded form of the lysosomal enzyme GBA1, whilst other lysosomal enzymes are associated with Alzheimer disease risk and show defective transport to the lysosome. The aim of this project is to use our skills in lysosomal biology and drug discovery (including AI), alongside structural biology, to identify new small molecule chemical chaperones for these enzymes and new therapies for these devastating diseases.

Lead Supervisor

Dr Emyr Lloyd-Evans

Lead Supervisor Email

University Affiliation