Neuroscience and Mental Health
Full Project Description
Please download the below document for a full project description and to see the full supervisory team.
A major risk gene for Parkinson disease encodes a mis-folded form of the lysosomal enzyme GBA1, whilst other lysosomal enzymes are associated with Alzheimer disease risk and show defective transport to the lysosome. The aim of this project is to use our skills in lysosomal biology and drug discovery (including AI), alongside structural biology, to identify new small molecule chemical chaperones for these enzymes and new therapies for these devastating diseases.
Dr Emyr Lloyd-Evans
Lead Supervisor Email