Clonal aging of anti-viral T cells impacts protective immunity

Project Code

MRCIIAR24Ca Ladell

Research Theme

Infection, Immunity, Antimicrobial Resistance and Repair

Full Project Description

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The induction and persistence of effective antigen(Ag)-specific memory T-cell responses is required to bestow long-term protection against infectious diseases, and hence is critical to vaccine development. However, evolution of such T-cell responses can lead to impaired secondary (e.g. to influenza virus) or aberrant (e.g. to Dengue virus) responses. The student will examine age and evolution of several Ag-specific T-cells responses at steady state and over time.

Lead Supervisor

Dr Kristin Ladell

Lead Supervisor Email

University Affiliation