Infection, Immunity, Antimicrobial Resistance and Repair
Full Project Description
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Beta-lactams (penicillins and related drugs) are the most important antibiotics. Beta-lactams inhibit penicillin-binding proteins (PBPs) but in resistant bacteria are hydrolysed by mechanistically related beta-lactamase enzymes. This project combines cutting-edge methods in structural biology and molecular simulations to study reactions of beta-lactams with both types of enzyme and inform new strategies to overcome beta-lactam resistance.
Professor James Spencer
Lead Supervisor Email