Penicillin Antibiotic Action and Resistance in a Bacterial “Superbug”

Project Code

MRCIIAR24Br Spencer

Research Theme

Infection, Immunity, Antimicrobial Resistance and Repair

Full Project Description

Please download the below document for a full project description and to see the full supervisory team.


Beta-lactams (penicillins and related drugs) are the most important antibiotics. Beta-lactams inhibit penicillin-binding proteins (PBPs) but in resistant bacteria are hydrolysed by mechanistically related beta-lactamase enzymes. This project combines cutting-edge methods in structural biology and molecular simulations to study reactions of beta-lactams with both types of enzyme and inform new strategies to overcome beta-lactam resistance.

Lead Supervisor

Professor James Spencer

Lead Supervisor Email

University Affiliation