Integrative analysis of whole genomes and transcriptomes from multiple cell types in rare disease patients

Project Code MRCPHS25Ex Frontini Research Theme Population Health Sciences Project Summary Download Summary Comprehensive genetic analysis using whole genome sequencing (WGS) still fails to identify the genetic cause of diseases in about 50% of patients with rare diseases. To increase…

Unveiling the Biomechanics of Diabetic Foot Ulcers: Identifying Critical Foot Load Profiles for Prevention and Treatment

Project Code MRCPHS25Ex Akrami Research Theme Population Health Sciences Project Summary Download Summary Diabetic foot issues pose significant challenges for patients and healthcare providers. Current evaluation methods are costly, invasive, and subjective. This study aims to address these problems by…

Genetic predisposition to accelerated ageing: targeting telomeres using sex hormone supplementation in Idiopathic Pulmonary Fibrosis

Project Code MRCPHS24Ex Scotton Research Theme Population Health Sciences Full Project Description Please download the below document for a full project description and to see the full supervisory team. Summary Lung fibrosis is a devastating disease which causes 1% of…

Understanding and addressing inequalities in the cancer diagnostic pathway for people with anxiety and/or depression

Project Code MRCPHS24Ex Price Research Theme Population Health Sciences Full Project Description Please download the below document for a full project description and to see the full supervisory team. Summary This multi-disciplinary PhD builds on Exeter and Cardiff research aiming…

Using modelling approaches to reduce inequality in physical activity interventions

Project Code MRCPHS24Ex Kelson Research Theme Population Health Sciences Full Project Description Please download the below document for a full project description and to see the full supervisory team. Summary Physical activity promotes health & wellbeing. Policy makers seek interventions…

Investigating the penetrance of cancer susceptibility genes in a population cohort and the influences of family history and rare and common genetic modifiers

Project Code MRCPHS24Ex Jackson Research Theme Population Health Sciences Full Project Description Please download the below document for a full project description and to see the full supervisory team. Summary Offering genetic testing only to those with a family history…

Integrative analysis of whole genomes and transcriptomes from multiple cell types in rare disease patients

Project Code MRCPHS24Ex Frontini Research Theme Population Health Sciences Full Project Description Please download the below document for a full project description and to see the full supervisory team. Summary The use of Whole-Genome Sequencing increased the diagnostic yield for…

Understanding how ethnic differences may influence diabetes diagnosis and control in pregnancy

Project Code MRCPHS24Ex Freathy Research Theme Population Health Sciences Full Project Description Please download the below document for a full project description and to see the full supervisory team. Summary When diabetes occurs in pregnancy, monitoring of maternal glucose is…

Investigating the epigenetic component of insulin secretion disorders

Project Code MRCPHS24Ex Dempster Research Theme Population Health Sciences Full Project Description Please download the below document for a full project description and to see the full supervisory team. Summary During this PhD, you will use innovative bioinformatic techniques to…