Project Code MRCNMH26Ca Ngo Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Neurodevelopmental disorders (NDDs) like autism and ADHD affect millions, yet the underlying causes remain unclear. This PhD project investigates how mutations in…
Novel area-modulation stimuli for identifying changes in visual field sensitivity in Age-related Macular Degeneration (AMD)
Project Code MRCNMH26Ca Redmond Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Age-related macular degeneration (AMD) is one of the world’s leading causes of sight loss. Traditional measures of vision in AMD are of…
When DNA Breaks and Mitochondria Fail: Investigating Drivers of Huntington’s Disease
Project Code MRCNMH26Ca Smith Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Huntington’s disease (HD) is a fatal inherited brain disorder with no effective treatment. It causes specific neurons in the brain to degenerate,…
Pain as neurobiological surprise: Using human brain imaging and animal studies to advance new concepts in persistent pain.
Project Code MRCNMH26Ca Tackley Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Complex nervous systems attempt to minimise surprise and aid survival by forming predictions about the world. Surprise signals danger: it is evidence…
Communication Breakdown: Using human assembloid models to understand disruption of neuron-glia interactions in ALS.
Project Code MRCNMH26Ex Bhinge Project Type Primarily wet-lab with a strong computational component. Research Theme Neuroscience and Mental Health Project Summary Download Summary ALS is a devastating neurological disease with no cure, and we urgently need new ways to understand…
Capturing the Molecular Basis of Altered Learning in Schizophrenia
Project Code MRCNMH26Ex Clifton Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary In this interdisciplinary PhD project, you will explore how memory is altered in schizophrenia by investigating the neurons activated during learning. Using…
Architects of the Genome: Using genomic technologies to elucidate the role of CTCF in neurodevelopmental disorders
Project Code MRCNMH26Ex Flynn Project Type The project is primarily wet-lab based, with a dry-lab component in Years 2 and 3. Research Theme Neuroscience and Mental Health Project Summary Download Summary Genetic variants in the CTCF gene, which encodes a…
Capturing primitive haematogenesis and microglia function ex vivo using human stem cell-based models
Project Code MRCNMH26Ex Guo Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary This project aims to uncover how early human immune cells, especially microglia (the brain’s immune cells), form during development. Since studying human…
Investigating the role microRNAs play in the pathophysiology of Huntington’s disease and whether they could be targeted therapeutically
Project Code MRCNMH26Ex Lunnon Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the HTT gene, with age of onset influenced by…
Epigenetic profiling in Parkinson’s disease: novel mechanisms and drug targets
Project Code MRCNMH26Ex Migdalska-Richards Project Type A particular strength of this project is that it combines both wet-lab work (microRNA profiling, cell culturing and transfection) and bioinformatics, allowing the student to acquire a valuable combination of skills that will be…