Project Code NMH27Ba Walton Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Epigenetic and structural brain alterations have been separately linked to neurodevelopmental and psychiatric conditions, but little is known about their combined impact…
You snooze, you win: harnessing hibernation biology for organ protection
Project Code NMH27Br Ambler Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Hibernating animals survive with barely-beating hearts and minimal oxygen. What if we could borrow that trick for critically ill patients? We’ve found…
Uncovering interneuron dysfunction in a mouse model of schizophrenia
Project Code NMH27Br Anastasiades Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary This project seeks to understand how disease-causing mutations linked to neurodevelopmental disorders, such as schizophrenia, alter cell types in the brain. The…
Can Virtual Reality (VR) embodiment experiences be used as part of treatment for eating disorders?
Project Code NMH27Br Bould Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Current treatments for eating disorders work for less than half of those affected, so it is vital to develop novel treatments. Virtual…
Cerebellar orchestration of social behaviour
Project Code NMH27Br Cahill Project Type Other Research Theme Neuroscience and Mental Health Project Summary Download Summary The cerebellum is increasingly recognised to contribute to behavioural flexibility and social cognition. Cerebellar changes are also a major risk factor for developing…
Decoding Early Brain and Movement Signals to Predict Outcomes after Birth Asphyxia
Project Code NMH27Br Chakkarapani Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Birth asphyxia occurs when a baby is deprived of oxygen around birth, causing brain injury, disability or death. This project will study…
Timing is Everything: Aligning Mealtime and Drug Treatment with the Body Clock to Fight Obesity
Project Code NMH27Br Chrobok Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Most physiological processes, including feeding, follow circadian (~24h) cycles. In mammals, these rhythms are generated by endogenous ‘body clocks’ within the brain.…
Alternative fates of PINK1 and its role in mitochondrial quality control, energy production and Parkinson’s Disease
Project Code NMH27Br Collinson Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Mitochondria are vital for energy production, cellular homeostasis, and health. This project explores how PINK1, key to mitochondrial quality control, is imported…
Molecular basis of CASK mutations and their role in neural development
Project Code NMH27Br Corey Project Type Other Research Theme Neuroscience and Mental Health Project Summary Download Summary This interdisciplinary PhD project will investigate how disease-causing mutations alter the structure and function of CASK, a key protein required for synaptic development,…
Mapping the biology of complex brain disorders: uncovering molecular pathways and identifying potential drug targets
Project Code NMH27Br D’Andrea Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Developing medicines to treat brain disorders such as schizophrenia has proven extremely difficult, with many new drugs failing in late-stage clinical trials.…