Project Code MRCNMH26Ex Mill Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Why do males and females show different risks for brain disorders like schizophrenia, depression, autism and Alzheimer’s? This project explores how sex…
Ketamine Use Disorder: Exploring Psychological and Neurological Mechanisms
Project Code MRCNMH26Ex Morgan Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Ketamine use disorder is the fastest growing addiction in the UK, with ~ 300% increase in people seeking treatment over the past…
Can supporting cells of the brain help to treat Alzheimer’s disease?
Project Code MRCNMH26Ex Noble Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Tau tangles accumulate mainly in neurons in Alzheimer’s disease brain. We recently found that blocking inflammatory signals in non-neuronal cells caused a…
Neuronal Clues to Astrocytes: Uncovering Hidden Mechanisms in the Developing Brain
Project Code MRCNMH26Ex Oguro-Ando Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary How do neuronal signals drive astrocyte-mediated changes in brain development? This project will investigate the underlying cellular and molecular mechanisms by which…
Explaining the elusive first step in neurodegenerative diseases by solving the structures of disordered proteins in physiological environments
Project Code MRCNMH26Ex Phillips Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Neurodegenerative diseases, such as Parkinson’s disease, are strongly linked to the aggregation of intrinsically disordered proteins (IDPs). However, the precise triggers and…
Risk vs. Protection: How Microglia Shape Neuronal Survival in Alzheimer’s disease
Project Code MRCNMH26Ex Piers Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Genetic variants in TREM2 and PLCG2 alter microglial responses in Alzheimer’s disease, but the consequences on neurons remain unclear. This project will…
Using machine learning to classify microglia
Project Code MRCNMH26Ex Richards Project Type One of the chief advantages of this proposed project is that it intimately combines both theoretical work (including mathematics, programming, image analysis and machine learning) with wet-lab work (including cell culture and time-lapse imaging).…
Genomics, oestrogen and the brain
Project Code MRCNMH26Ex Ruth Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary We will use ‘big data’ genomic analyses to investigate the genetics and neuroscience underlying oestrogen-related traits. For example, lower oestrogen following menopause…
Functional analysis of novel rare coding variants for schizophrenia using zebrafish
Project Code MRCNMH26Ex Ryu Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Schizophrenia is a severe psychiatric disorder with debilitating effects on a patient’s quality of life. Because current medications do not work well,…
Exploiting novel lipid binding proteins to tackle neurological disorders
Project Code MRCNMH26Ex Schrader Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Successful applicants will join a dynamic, multi-disciplinary research project at the forefront of molecular cell biology, neurobiology, and lipid biochemistry. This cutting-edge…