Project Code
MRCNMH25Ex Basson
Research Theme
Neuroscience & Mental Health
Project Summary Download
Summary
The Kdm5b gene is linked to a number of neurodevelopmental disorders, including ADHD, autism, bipolar disorder and intellectual disability. Using a unique mouse model, we recently identified a neurobiological mechanism that underlies socio-communicative deficits in this model and showed that taregtting this mechanism can restore normal function. The aim of this project is to use cutting-edge approaches to identify the brain regions and cell types that control these behaviours, study the brain circuits affected by Kdm5b deficiency and understand how treatments can restore normal function. This research will have important implications for understanding socio-communicative deficits in neurodevelopmental disorders.
Lead Supervisor
Professor Albert Basson
Lead Supervisor Email
m.a.basson@exeter.ac.uk
University Affiliation
Cardiff