Project Code MRCNMH25Ex Housden Research Theme Neuroscience & Mental Health Project Summary Download Summary The aim of this project is to understand the mechanisms that cause motor neuron disease (MND) so that new treatments can be developed. This is important…
The consequence of mitochondrial import failure in neurogenerative disease
Project Code MRCNMH25Ex Gold Research Theme Neuroscience & Mental Health Project Summary Download Summary Mitochondria provide energy essential for life and are dependent on the delivery of proteins from the cytosol for their biogenesis, maintenance and regeneration. Defects in protein…
Artificial Intelligence-enhanced mobile Behavioural Activation therapy for Dementia and Mild cognitive impairment (AI-BADeM)
Project Code MRCNMH25Ex Fox Research Theme Neuroscience & Mental Health Project Summary Download Summary Dementia affects around 55 million people globally, often leading to depression and unhealthy behaviours like physical inactivity and social isolation. These issues can worsen cognitive decline…
Epigenetic mechanisms in stem cell models of Rett syndrome
Project Code MRCNMH25Ex Flynn Research Theme Neuroscience & Mental Health Project Summary Download Summary Rett syndrome (RTT) is a neurodevelopmental disorder that causes physical and mental disability from early childhood. It is characterised by impaired motor and cognitive function and…
Cell-type-specific epigenetic regulation of gene expression in Motor Neuron Disease
Project Code MRCNMH25Ex Dempster Research Theme Neuroscience & Mental Health Project Summary Download Summary This project aims to uncover new molecular insights into Motor Neuron Disease (MND) using advanced molecular technologies. It involves studying human post-mortem brain tissue and cells…
Enhancing stem cell-derived motor neuron function as a therapeutic approach in Amyotrophic Lateral Sclerosis
Project Code MRCNMH25Ex Brown Research Theme Neuroscience & Mental Health Project Summary Download Summary Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, for which there is currently no effective treatment. In this project, you will use human motor neurons…
Understanding the social brain circuits affected in neurodevelopmental disorders
Project Code MRCNMH25Ex Basson Research Theme Neuroscience & Mental Health Project Summary Download Summary The Kdm5b gene is linked to a number of neurodevelopmental disorders, including ADHD, autism, bipolar disorder and intellectual disability. Using a unique mouse model, we recently…
Recognising uniquely human emotions
Project Code MRCNMH25Ca von dem Hagen Research Theme Neuroscience & Mental Health Project Summary Download Summary Being able to read other people’s emotions can convey considerable social benefits. But it remains unclear how humans perceive others’ uniquely human emotions (such…
Biomarker discovery of inflammatory pathways linked to mood and autoimmune disorders
Project Code MRCNMH25Ca Szomolay Research Theme Neuroscience & Mental Health Project Summary Download Summary “Mood disorders (MDs), e.g. depression, affect over one billion people worldwide. MDs show a bidirectional relationship with systemicinflammation, a key component in the pathophysiology of autoimmune…
How does DNA damage and mitochondrial dysfunction contribute to Huntington’s disease?
Project Code MRCNMH25Ca Smith Research Theme Neuroscience & Mental Health Project Summary Download Summary Huntington’s disease (HD) is an inherited disorder that causes specific neurons in the brain to die. HD patients develop uncontrollable movements as well as cognitive and…