Project Code
MRCIIAR25Ba Lovell
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
Infections with drug-resistant bacteria are major threats to human health. Discovering novel druggable targets for antimicrobial development is a pivotal task to guarantee effective future treatments. This interdisciplinary project will target WalK, a protein kinase essential for the viability of S. aureus cells. Large libraries of covalent macrocycles will be screened against WalK to identify an inhibitor. Hit-to-lead optimization will be achieved using a suite of chemical, structural and molecular methods. Finally, lead molecules will be applied in vivo using an invertebrate infection model. Ultimately, this work will provide novel antimicrobial compounds ready for pre-clinical assessment in mice.
Lead Supervisor
Dr Scott Lovell
Lead Supervisor Email
sdl35@bath.ac.uk
University Affiliation
Bath