Project Code MRCIIAR26Ex Padfield Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Recent studies have shown that levels of antimicrobial resistance (AMR) increase at higher environmental temperatures, but we have limited understanding…
Establishing a humanised zebrafish model for studying the genetic resilience in Neurofibromatosis Type 1 (NF1)
Project Code MRCIIAR26Ex Scholpp Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary This PhD project explores the phenomenon of “genetic resilience” in the context of Malignant Peripheral Nerve Sheath Tumours (MPNSTs), aggressive…
Developing CRISPR-Cas antimicrobials to tackle antibiotic resistance spread in Klebsiella pneumoniae
Project Code MRCIIAR26Ex van Houte Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antimicrobial resistance (AMR) poses a major threat to human health, which is for a large part driven by plasmids…
Novel phage-based therapeutics against drug-resistant bacteria
Project Code MRCIIAR26Ex Westra Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antibiotic-resistant Pseudomonas aeruginosa is a major global health threat, causing infections that are increasingly difficult to treat. This project will…
Quantifying Rapid Evolution of Thermal Tolerance in the Novel Pathogenic Fungus Candida auris (Candidozyma auris)
Project Code MRCIIAR26Ex Yvon-Durocher Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Periodic episodes of high temperature associated with global climate change may be driving changes in the host range of pathogens,…
Synthetic heroin: understanding the dangers of nitazene drugs
Project Code MRCNMH26Ba Bailey Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Drug-related deaths are now at the highest ever recorded in the UK, the majority involving opioid drugs. Currently, a new class of…
Neural Mechanisms of Pain Relief: Comparing Cognitive Training and Neurostimulation Interventions
Project Code MRCNMH26Ba Khatibi Project Type Wet and dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Neuropathic pain (like diabetic-related peripheral neuropathy) is a persistent condition where the source of the pain isn’t tissue injury. Instead,…
Tackling Alzheimer’s with Smart Protein Removal Tools
Project Code MRCNMH26Ba Licchesi Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Targeted Protein Degradation (TPD) is a new approach that helps cells remove harmful proteins linked to diseases like Alzheimer’s. It uses special…
Selective Dephosphorylation of α-Synuclein in Parkinson’s Using PhosTAC Peptides
Project Code MRCNMH26Ba Mason Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Phosphorylation of the protein α-synuclein at serine 129 (pS129) is a defining feature of Parkinson’s disease and related conditions. This project will…
RNA-dependent regulation of the KAP1 chromatin protein controls neuronal stem cell function
Project Code MRCNMH26Ba Vance Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary The mammalian genome encodes hundreds of RNA binding proteins that associate with RNA using poorly defined modes of action. Mutations in these…