Project Code MRCNMH26Br Purple Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Why do some people recover from trauma while others develop post-traumatic stress disorder (PTSD)? Sleep is known to play an essential role…
A High-Efficiency and Sustainable Next-Generation Nanotherapeutic platform to Improve Astrocytoma Outcomes
Project Code MRCNMH26Ca Duc Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary In 2023, the Welsh and UK Government emphasised the urgent need for astrategic plan prioritising research in brain tumour therapy. Astrocytoma,comprising 1/3…
How ADHD affects curiosity and curiosity-based learning
Project Code MRCNMH26Ca Gruber Project Type The project will combine behavioural and neuroimaging studies (in particular, functional Magnetic Resonance Imaging, fMRI) in human participants. Research Theme Neuroscience and Mental Health Project Summary Download Summary This PhD project explores how curiosity…
SONIC-Glaucoma: Stimulation Of Neuroprotective & Immunomodulatory Cargos via Ultrasound in Glaucoma
Project Code MRCNMH26Ca Mead Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Glaucoma causes progressive retinal ganglion cell (RGC) loss and remains without effective neuroprotective therapy. While platelet-derived growth factor (PDGF) and brain-derived neurotrophic…
Investigating Neurodevelopmental Disorders Through the Lens of UPF3B Syndrome
Project Code MRCNMH26Ca Ngo Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Neurodevelopmental disorders (NDDs) like autism and ADHD affect millions, yet the underlying causes remain unclear. This PhD project investigates how mutations in…
When DNA Breaks and Mitochondria Fail: Investigating Drivers of Huntington’s Disease
Project Code MRCNMH26Ca Smith Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Huntington’s disease (HD) is a fatal inherited brain disorder with no effective treatment. It causes specific neurons in the brain to degenerate,…
Pain as neurobiological surprise: Using human brain imaging and animal studies to advance new concepts in persistent pain.
Project Code MRCNMH26Ca Tackley Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Complex nervous systems attempt to minimise surprise and aid survival by forming predictions about the world. Surprise signals danger: it is evidence…
Communication Breakdown: Using human assembloid models to understand disruption of neuron-glia interactions in ALS.
Project Code MRCNMH26Ex Bhinge Project Type Primarily wet-lab with a strong computational component. Research Theme Neuroscience and Mental Health Project Summary Download Summary ALS is a devastating neurological disease with no cure, and we urgently need new ways to understand…
Capturing the Molecular Basis of Altered Learning in Schizophrenia
Project Code MRCNMH26Ex Clifton Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary In this interdisciplinary PhD project, you will explore how memory is altered in schizophrenia by investigating the neurons activated during learning. Using…
Architects of the Genome: Using genomic technologies to elucidate the role of CTCF in neurodevelopmental disorders
Project Code MRCNMH26Ex Flynn Project Type The project is primarily wet-lab based, with a dry-lab component in Years 2 and 3. Research Theme Neuroscience and Mental Health Project Summary Download Summary Genetic variants in the CTCF gene, which encodes a…