Project Code
MRCNMH26Ex Ruth
Project Type
Dry lab
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
We will use ‘big data’ genomic analyses to investigate the genetics and neuroscience underlying oestrogen-related traits. For example, lower oestrogen following menopause is thought to affect cell signalling in the hypothalamus causing menopausal symptoms, and has also been linked to cognitive decline. The student will investigate the genetic basis and biological mechanisms of oestrogen-related traits by integrating experimental cellular multi-omics data with cutting-edge whole genome sequencing analyses in population-based cohorts of 100,000s of people. The genes identified will be used in genetic epidemiological approaches to test relationships between oestrogen and brain-related health conditions, providing aetiological insights.
Lead Supervisor
Dr Katherine Ruth
Lead Supervisor Email
University Affiliation
Exeter