Project Code
IIAR27Ba Preston
Project Type
Wet lab
Research Theme
Infection, Immunity, and Antimicrobial Resistance
Project Summary Download
Summary
Respiratory cilia are largely regarded as purely mechanical, sweeping particles trapped in mucus out of the respiratory tract. However, they contain key signalling molecules, suggesting sensory and response functions. We will investigate this uncharacterised aspect of cilia biology. We will exploit the exquisite specificity of Bordetella bacteria for adherence to respiratory cilia that involves several different protein adhesins that engage currently unknown cilia receptors to alter ciliary beat patterns. We will characterise adhesin-receptor interactions, intracilia signalling induced by receptor engagement and the results of this signalling. This will redefine our understanding of sensing and responses at the respiratory epithelium surface.
Can the project be completed part time?
No
Lead Supervisor
Professor Andrew Preston
Lead Supervisor Email
University Affiliation
University of Bath
