Project Code
CMD27Ba Koumanov
Project Type
Wet lab
Research Theme
Cardiometabolic Disease
Project Summary Download
Summary
Very-low carbohydrate ketogenic diets (KDs) can improve body weight and blood glucose but often raise LDL-cholesterol levels, thereby increasing cardiovascular risk. A key unknown is whether the saturated to polyunsaturated fat ratio in a KD, affects cardiovascular risk. This PhD project will investigate how the fat quality in a KD affects cardiovascular health in a 4-week human trial and gain mechanistic understanding of how the body adapts to such diets using genetic epidemiology and cell culture models. The goal is to determine whether altering fat quality can deliver KD benefits without increasing LDL-cholesterol, improving safety and cardiometabolic health.
Can the project be completed part time?
No
Lead Supervisor
Dr Francoise Koumanov
Lead Supervisor Email
University Affiliation
University of Bath
