Epigenetic regulation of microglial gene expression in Alzheimer’s disease

Project Code

MRCIIAR24Ca Peters

Research Theme

Infection, Immunity, Antimicrobial Resistance and Repair

Full Project Description

Please download the below document for a full project description and to see the full supervisory team.


Neuroinflammation is a prominent event Alzheimer’s disease (AD) pathogenesis driven by activation of microglia, the brains resident immune cells. To define how microglial gene expression is regulated in AD, this project utilises a state-of-the-art human stem cell culture model of AD coupled with epigenomic profiling and bioinformatic analysis. The role of prioritised genes will then be described through functional assays of important microglial processes.

Lead Supervisor

Dr Owen Peters

Lead Supervisor Email


University Affiliation