Infection, Immunity, Antimicrobial Resistance and Repair
Full Project Description
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Neuroinflammation is a prominent event Alzheimer’s disease (AD) pathogenesis driven by activation of microglia, the brains resident immune cells. To define how microglial gene expression is regulated in AD, this project utilises a state-of-the-art human stem cell culture model of AD coupled with epigenomic profiling and bioinformatic analysis. The role of prioritised genes will then be described through functional assays of important microglial processes.
Dr Owen Peters
Lead Supervisor Email