Project Code MRCIIAR26Ex Padfield Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Recent studies have shown that levels of antimicrobial resistance (AMR) increase at higher environmental temperatures, but we have limited understanding…
Establishing a humanised zebrafish model for studying the genetic resilience in Neurofibromatosis Type 1 (NF1)
Project Code MRCIIAR26Ex Scholpp Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary This PhD project explores the phenomenon of “genetic resilience” in the context of Malignant Peripheral Nerve Sheath Tumours (MPNSTs), aggressive…
Developing CRISPR-Cas antimicrobials to tackle antibiotic resistance spread in Klebsiella pneumoniae
Project Code MRCIIAR26Ex van Houte Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antimicrobial resistance (AMR) poses a major threat to human health, which is for a large part driven by plasmids…
Novel phage-based therapeutics against drug-resistant bacteria
Project Code MRCIIAR26Ex Westra Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antibiotic-resistant Pseudomonas aeruginosa is a major global health threat, causing infections that are increasingly difficult to treat. This project will…
Quantifying Rapid Evolution of Thermal Tolerance in the Novel Pathogenic Fungus Candida auris (Candidozyma auris)
Project Code MRCIIAR26Ex Yvon-Durocher Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Periodic episodes of high temperature associated with global climate change may be driving changes in the host range of pathogens,…
Communication Breakdown: Using human assembloid models to understand disruption of neuron-glia interactions in ALS.
Project Code MRCNMH26Ex Bhinge Project Type Primarily wet-lab with a strong computational component. Research Theme Neuroscience and Mental Health Project Summary Download Summary ALS is a devastating neurological disease with no cure, and we urgently need new ways to understand…
Capturing the Molecular Basis of Altered Learning in Schizophrenia
Project Code MRCNMH26Ex Clifton Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary In this interdisciplinary PhD project, you will explore how memory is altered in schizophrenia by investigating the neurons activated during learning. Using…
Architects of the Genome: Using genomic technologies to elucidate the role of CTCF in neurodevelopmental disorders
Project Code MRCNMH26Ex Flynn Project Type The project is primarily wet-lab based, with a dry-lab component in Years 2 and 3. Research Theme Neuroscience and Mental Health Project Summary Download Summary Genetic variants in the CTCF gene, which encodes a…
Capturing primitive haematogenesis and microglia function ex vivo using human stem cell-based models
Project Code MRCNMH26Ex Guo Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary This project aims to uncover how early human immune cells, especially microglia (the brain’s immune cells), form during development. Since studying human…
Investigating the role microRNAs play in the pathophysiology of Huntington’s disease and whether they could be targeted therapeutically
Project Code MRCNMH26Ex Lunnon Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the HTT gene, with age of onset influenced by…