Project Code MRCPHS25Ex Hawkes Research Theme Population Health Sciences Project Summary Download Summary A person’s health is influenced by their socioeconomic status, smoking and other behavioural and environmental factors, as well as their genetic make-up. Some genetic variants directly affect…
Combining technologies to elucidate the epigenome’s impact on health and disease
Project Code MRCPHS25Ex Hannon Research Theme Population Health Sciences Project Summary Download Summary The epigenome’s dynamic nature and it’s responsiveness to environmental changes make it particularly attractive in the study of health and disease. This interest has resulted in various…
Integrative analysis of whole genomes and transcriptomes from multiple cell types in rare disease patients
Project Code MRCPHS25Ex Frontini Research Theme Population Health Sciences Project Summary Download Summary Comprehensive genetic analysis using whole genome sequencing (WGS) still fails to identify the genetic cause of diseases in about 50% of patients with rare diseases. To increase…
Unveiling the Biomechanics of Diabetic Foot Ulcers: Identifying Critical Foot Load Profiles for Prevention and Treatment
Project Code MRCPHS25Ex Akrami Research Theme Population Health Sciences Project Summary Download Summary Diabetic foot issues pose significant challenges for patients and healthcare providers. Current evaluation methods are costly, invasive, and subjective. This study aims to address these problems by…
Characterising a new neuroimmune pathway to treat Alzheimer’s disease
Project Code MRCNMH25Ex Witton Research Theme Neuroscience & Mental Health Project Summary Download Summary Microglia are brain-resident immune cells. Alongside conventional molecular signals, the latest research suggests that specific patterns of brain activity can control microglia function. We have found…
Metabolic psychiatry – Understanding ethnic and global differences in the inter-relationships between obesity and mental health
Project Code MRCNMH25Ex Tyrrell Research Theme Neuroscience & Mental Health Project Summary Download Summary Many people live with multiple health conditions, but research still tends to focus on individual diseases. This project, focuses on two global health problems with a…
Exploiting lipid binding proteins to tackle neurological disorders
Project Code MRCNMH25Ex Schrader Research Theme Neuroscience & Mental Health Project Summary Download Summary This multi-disciplinary project combines cutting-edge molecular cell biology, neurobiological, and biochemical (lipid analysis) approaches to reveal novel links between organelle membrane proteins, lipid metabolism, and neurodegenerative…
Assuming associations from old data- the case of ADHD and drug use
Project Code MRCNMH25Ex Russell Research Theme Neuroscience & Mental Health Project Summary Download Summary Many research papers about ADHD include the sentence “ADHD is associated with increased risk of substance use”. However, new analysis in UK datasets has shown no…
Using machine learning to classify microglia
Project Code MRCNMH25Ex Richards Research Theme Neuroscience & Mental Health Project Summary Download Summary During this exciting, fully-funded PhD, you will use machine learning to automatically classify the state of microglia (the brain’s specialised immune cells). This will involve combining…
Mapping Preterm Sleep Microstructure and EEG Biomarkers for Early Neurodevelopmental Risk Assessment
Project Code MRCNMH25Ex Poorun Research Theme Neuroscience & Mental Health Project Summary Download Summary Sleep is crucial for early brain development, yet preterm infants often have disrupted sleep patterns that may impact their long-term outcomes. This project will use advanced…