Understanding the role of disease-causing NMDA receptor mutations in synaptic development and function

Project Code

MRCNMH24Br Anastasiades

Research Theme

Neuroscience and Mental Health

Full Project Description

Please download the below document for a full project description and to see the full supervisory team.

Summary

Neurodevelopmental disorders are a major global health burden. One main challenge is understanding how, despite influencing the same genes, individual mutations can cause distinct symptoms, that emerge at distinct stages of development. This project combines mouse genetics, high-throughput imaging, and sophisticated circuit and behavioural analyses to understand how mutations in the NMDA receptor gene NR2A cause changes to brain development and function.

Lead Supervisor

Dr Paul Anastasiades

Lead Supervisor Email

paul.anastasiades@bristol.ac.uk

University Affiliation

Bristol