Understanding the link between lipid droplet biology and bone health

Project Code

CMD27Br Carroll

Project Type

Wet lab

Research Theme

Cardiometabolic Disease

Project Summary Download

Summary

Cells require a tightly regulated supply of lipids to sustain metabolism and growth. When lipids are abundant, fatty acids are packaged into lipid droplets, which act as an energy reserve. We recently identified a new regulator of lipid droplets and interestingly, analysis of large genetic datasets and in vivo models implicates this gene in bone growth and health. Using a combination of molecular genetics, mechanistic cell biology and in vivo models, the aim of this PhD is to reveal new understanding of how lipid droplets regulate bone health and disease.

Can the project be completed part time?

Yes

Lead Supervisor

Dr Bernadette Carroll

Lead Supervisor Email

bernadette.carroll@bristol.ac.uk

University Affiliation

University of Bristol

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