Project Code CMD27Br Mosienko Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary The heart is controlled by the peripheral nervous system, whose nerves are supported by “helper” cells called glia, as astrocytes support neurons in the…
Targeted gene integration therapy for cystinosis
Project Code CMD27Br Saleem Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Cystinosis is a rare condition caused by mutations in the CTNS gene. This leads to cystine build-up in cells which damages many organs, especially…
Linking structure, function and genomics at single cell resolution: an integrative approach to understanding inherited heart disease
Project Code CMD27Ca Fowler Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary This project aims to address a research priority for patients with the inherited heart condition, hypertrophic cardiomyopathy (HCM), by investigating how the same mutation…
Decoding calcium signalling during fertilization: a data-driven mathematical modelling framework for a non-invasive IVF diagnostic tool
Project Code CMD27Ca Kaouri Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary In vitro fertilization (IVF) is the primary treatment for infertility, with over 2.5 million cycles performed annually worldwide. Success rates remain limited because the…
Disentangling Diabetes: A Novel Genetic Decomposition Approach
Project Code CMD27Ex Beaumont Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Diabetes is a highly heterogeneous condition, but its clinical management relies heavily on HbA1c – a biomarker affected by distinct pathways: glucose metabolism (glycaemic)…
Data-Driven Precision Medicine in the Hospital: Advanced Blood Glucose Analytics to Improve Inpatient Diabetes Care
Project Code CMD27Ex Dennis Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary 20%-30% of NHS hospital beds are occupied by people with diabetes, who often experience poorer clinical outcomes due to unstable blood sugar levels (adverse…
Understanding the causes, and best treatment, of type 2 diabetes in people who are not overweight
Project Code CMD27Ex Jones Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Many people think of type 2 diabetes as being a condition that affects people with high body weight, but millions of people with type…
Genetic and Therapeutic Determinants of Adverse Drug Reactions in Cardio-Renal Diseases
Project Code CMD27Ex Pilling Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Why do people with cardiometabolic diseases experience different health trajectories despite similar treatment? This interdisciplinary PhD project will investigate how genetic variation, prescribing, and…
Metabolic adaptation to a low carbohydrate ketogenic diet and its effects on exercise fuel use and glucose management in physically active people with Type 1 Diabetes
Project Code CMD27Ex Podlogar Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Ketogenic diet (very low in carbohydrate, high in fat) is increasingly popular among people with Type 1 Diabetes (T1D). In principle, a ketogenic diet…
Understanding Muscle Metabolism Responses to Feeding in Adult Survivors of Childhood Acute lymphoblastic Leukaemia
Project Code CMD27Ex Revuelta Iniesta Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Survivors of childhood acute lymphoblastic leukaemia (ALL) experience premature frailty (age 44) defined by muscle atrophy. Muscle protein synthesis is crucial for muscle…