Discovery and functional testing of Alzheimer’s disease risk–resilience pathways in human iPSC microglia

Project Code NMH27Ex Piers Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Late onset Alzheimer’s disease (LOAD) risk is shaped by microglial genes, particularly the TREM2 signalling axis. The coding mutation TREM2 R47H increases…

Cross-species modelling of rare coding variants associated withschizophrenia

Project Code NMH27Ex Ryu Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Schizophrenia is a severe psychiatric disorder with debilitating effects on a patient’s quality of life. Because current medications do not work well,…

Not Enough Money for Food and Struggling to Eat: Understanding the Connection Between Food Insecurity and Disordered Eating

Project Code NMH27Ex Turk Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary ARFID is an eating disorder where people avoid foods due to sensory sensitivities, fear of choking or vomiting, or low interest in…

Severe mental illness, inflammation and cardiometabolic health

Project Code NMH27Ex Tyrrell Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary This exciting PhD combines big data and genetics to understand the complex relationships between severe mental illness, inflammation, and obesity and other…

Investigating molecular mechanisms underlying resilience to dementia and age-related disorders: A multi-omic analysis of large human biobanks

Project Code NMH27Ex Walker Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Why do some people remain cognitively healthy despite being at high genetic risk of dementia? This project will use cutting-edge genetic and…

Unraveling Moral Injury in Eating Disorders in Young Adults

Project Code NMH27Ex Zasiekina Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary This PhD investigates the role of moral injury in eating disorders (EDs) by examining neurocognitive mechanisms through fMRI, psychometric assessment, and qualitative…