Project Code MRCIIAR26Ex Westra Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antibiotic-resistant Pseudomonas aeruginosa is a major global health threat, causing infections that are increasingly difficult to treat. This project will…
Quantifying Rapid Evolution of Thermal Tolerance in the Novel Pathogenic Fungus Candida auris (Candidozyma auris)
Project Code MRCIIAR26Ex Yvon-Durocher Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Periodic episodes of high temperature associated with global climate change may be driving changes in the host range of pathogens,…
Synthetic heroin: understanding the dangers of nitazene drugs
Project Code MRCNMH26Ba Bailey Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Drug-related deaths are now at the highest ever recorded in the UK, the majority involving opioid drugs. Currently, a new class of…
Neural Mechanisms of Pain Relief: Comparing Cognitive Training and Neurostimulation Interventions
Project Code MRCNMH26Ba Khatibi Project Type Wet and dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Neuropathic pain (like diabetic-related peripheral neuropathy) is a persistent condition where the source of the pain isn’t tissue injury. Instead,…
Tackling Alzheimer’s with Smart Protein Removal Tools
Project Code MRCNMH26Ba Licchesi Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Targeted Protein Degradation (TPD) is a new approach that helps cells remove harmful proteins linked to diseases like Alzheimer’s. It uses special…
Selective Dephosphorylation of α-Synuclein in Parkinson’s Using PhosTAC Peptides
Project Code MRCNMH26Ba Mason Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Phosphorylation of the protein α-synuclein at serine 129 (pS129) is a defining feature of Parkinson’s disease and related conditions. This project will…
RNA-dependent regulation of the KAP1 chromatin protein controls neuronal stem cell function
Project Code MRCNMH26Ba Vance Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary The mammalian genome encodes hundreds of RNA binding proteins that associate with RNA using poorly defined modes of action. Mutations in these…
Transforming Obesity Care in Idiopathic Intracranial Hypertension: A Person-Centred, Multidisciplinary Approach
Project Code MRCNMH26Br Atan Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Idiopathic intracranial hypertension (IIH) is a serious neurological condition linked to obesity—but weight loss isn’t simple when disordered eating, trauma, and mental…
Chrono-nutrition and Chrono-pharmacology: Investigating the Impact of Intermittent Fasting and Timed Pharmacological Treatments for Obesity Management
Project Code MRCNMH26Br Chrobok Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Most physiological processes, including feeding, follow circadian (~24h) cycles. In mammals, these rhythms are generated by endogenous ‘body clocks’ within the brain.…
Alternative mitochondrial destinations of PINK1 and its role in Parkinson’s Disease
Project Code MRCNMH26Br Collinson Project Type It is both a wet and a dry project. Research Theme Neuroscience and Mental Health Project Summary Download Summary Mitochondria are vital for energy production, cell function and homeostasis, and thereby health. This project…