Project Code MRCNMH26Ex Noble Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Tau tangles accumulate mainly in neurons in Alzheimer’s disease brain. We recently found that blocking inflammatory signals in non-neuronal cells caused a…
Neuronal Clues to Astrocytes: Uncovering Hidden Mechanisms in the Developing Brain
Project Code MRCNMH26Ex Oguro-Ando Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary How do neuronal signals drive astrocyte-mediated changes in brain development? This project will investigate the underlying cellular and molecular mechanisms by which…
Explaining the elusive first step in neurodegenerative diseases by solving the structures of disordered proteins in physiological environments
Project Code MRCNMH26Ex Phillips Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Neurodegenerative diseases, such as Parkinson’s disease, are strongly linked to the aggregation of intrinsically disordered proteins (IDPs). However, the precise triggers and…
Risk vs. Protection: How Microglia Shape Neuronal Survival in Alzheimer’s disease
Project Code MRCNMH26Ex Piers Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Genetic variants in TREM2 and PLCG2 alter microglial responses in Alzheimer’s disease, but the consequences on neurons remain unclear. This project will…
Using machine learning to classify microglia
Project Code MRCNMH26Ex Richards Project Type One of the chief advantages of this proposed project is that it intimately combines both theoretical work (including mathematics, programming, image analysis and machine learning) with wet-lab work (including cell culture and time-lapse imaging).…
Functional analysis of novel rare coding variants for schizophrenia using zebrafish
Project Code MRCNMH26Ex Ryu Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Schizophrenia is a severe psychiatric disorder with debilitating effects on a patient’s quality of life. Because current medications do not work well,…
Exploiting novel lipid binding proteins to tackle neurological disorders
Project Code MRCNMH26Ex Schrader Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Successful applicants will join a dynamic, multi-disciplinary research project at the forefront of molecular cell biology, neurobiology, and lipid biochemistry. This cutting-edge…
Unlocking a new neuroimmune strategy to treat Alzheimer’s disease
Project Code MRCNMH26Ex Witton Project Type Wet lab Research Theme Population Health Science Project Summary Download Summary Microglia are the brain’s resident immune cells. The latest research suggests that, alongside conventional molecular signals, microglia function is also influenced by certain…
Unveiling the Journey from Action Potential to Behaviour: Exploring Dopamine and Acetylcholine in Health and Disease
Project Code MRCNMH26Ex Zhang Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary How does the brain’s dopamine system drive learning, memory, and motivation? And what goes wrong in diseases like Parkinson’s? This project will…
Under pressure: Investigating the role of breast density and tissue mechanics in breast cancer development
Project Code MRCPHS26Br Lloyd-Lewis Project Type Wet lab Research Theme Population Health Science Project Summary Download Summary A high breast mammographic density is a major risk factor for breast cancer, yet the underlying molecular mechanisms remain unclear. In this interdisciplinary…