Project Code
NMH27Br Corey
Project Type
Other
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
This interdisciplinary PhD project will investigate how disease-causing mutations alter the structure and function of CASK, a key protein required for synaptic development, neuronal communication, and brain function. Mutations in CASK cause severe neurodevelopmental disorders, including intellectual disability and microcephaly. The student will combine cutting-edge AI-based protein structure prediction tools, including AlphaFold3, with advanced structural bioinformatics to analyse pathogenic variants, uncover mechanisms of disease, and develop methods for prioritising clinically relevant mutations. The project offers training in AI, computational biology, and neuroscience, providing highly transferable skills for careers in academia, biotechnology, and biomedical research.
Can the project be completed part time?
Yes
Lead Supervisor
Dr Robin Corey
Lead Supervisor Email
University Affiliation
University of Bristol
