Project Code
NMH27Br Ambler
Project Type
Wet lab
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
Hibernating animals survive with barely-beating hearts and minimal oxygen. What if we could borrow that trick for critically ill patients? We’ve found that even non-hibernators like rats retain the brain circuitry for torpor — and switching it on halves heart-attack damage (40% smaller infarcts). This PhD asks how. Does protection still work if torpor starts after injury, as in a real heart attack? Are kidneys protected too? And how does the brain trigger these defences? You’ll master systems neuroscience, ischaemia-reperfusion models, in-vivo physiology and ‘omics — moving a bold idea closer to the clinic.
Can the project be completed part time?
Yes
Lead Supervisor
Dr Mike Ambler
Lead Supervisor Email
University Affiliation
University of Bristol
