Project Code
IIAR27Ca Pearson
Project Type
Wet lab
Research Theme
Infection, Immunity, and Antimicrobial Resistance
Project Summary Download
Summary
Prostate cancer remains a leading cause of cancer mortality, particularly in metastatic disease where treatment options are limited. This PhD project seeks to investigate the role of CD200, an immune checkpoint protein enriched in prostate cancer stem cells, in promoting tumour growth and immune evasion. Using genetic and pharmacological approaches, the study will evaluate a novel CD200 small molecule inhibitor to determine its effects on cancer stem cell function, tumour immunity and treatment response. The project will also assess whether combining CD200 inhibition with conventional immunotherapy enhances anti-tumour immune responses, providing a potential new therapeutic strategy for advanced prostate cancer.
Can the project be completed part time?
Yes
Lead Supervisor
Dr Helen Pearson
Lead Supervisor Email
University Affiliation
Cardiff University
