Project Code
CMD27Ex Revuelta Iniesta
Project Type
Wet lab
Research Theme
Cardiometabolic Disease
Project Summary Download
Summary
Survivors of childhood acute lymphoblastic leukaemia (ALL) experience premature frailty (age 44) defined by muscle atrophy. Muscle protein synthesis is crucial for muscle growth and relies on physical activity and dietary protein; however, observational data showed that protein intakes in ALL survivors do not differ from the general population, suggesting that the skeletal muscle may have an inability to respond normally to dietary stimuli, known as anabolic resistance. This study will explore if anabolic resistance is the cause of frailty in ALL survivors in response to diet. The results will guide the design of tailored dietary and exercise interventions.
Can the project be completed part time?
Yes
Lead Supervisor
Dr Raquel Revuelta Iniesta
Lead Supervisor Email
r.revuelta-iniesta@exeter.ac.uk
University Affiliation
University of Exeter
