Project Code NMH27Br Chrobok Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Most physiological processes, including feeding, follow circadian (~24h) cycles. In mammals, these rhythms are generated by endogenous ‘body clocks’ within the brain.…
Alternative fates of PINK1 and its role in mitochondrial quality control, energy production and Parkinson’s Disease
Project Code NMH27Br Collinson Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Mitochondria are vital for energy production, cellular homeostasis, and health. This project explores how PINK1, key to mitochondrial quality control, is imported…
Molecular basis of CASK mutations and their role in neural development
Project Code NMH27Br Corey Project Type Other Research Theme Neuroscience and Mental Health Project Summary Download Summary This interdisciplinary PhD project will investigate how disease-causing mutations alter the structure and function of CASK, a key protein required for synaptic development,…
Mapping the biology of complex brain disorders: uncovering molecular pathways and identifying potential drug targets
Project Code NMH27Br D’Andrea Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Developing medicines to treat brain disorders such as schizophrenia has proven extremely difficult, with many new drugs failing in late-stage clinical trials.…
What drives the pain? Exploring the peripheral component in models of central sensitisation
Project Code NMH27Br Dunham Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Chronic primary pain affects 8 million UK adults, but we still do not understand what drives pain when there is no identifiable…
Developing brain-activity based non-invasive stimulation techniques for movement disorders
Project Code NMH27Br Fischer Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Parkinson’s disease and dystonia can severely affect movement, and existing treatments do not work well for everyone. This PhD project will develop…
Gatekeepers of GPCR Signalling: Degradation Pathways in Health and Disease
Project Code NMH27Br Grieve Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Neuropsychiatric disorders remain among the greatest challenges in medicine, yet we still lack a detailed understanding of how changes at the molecular…
Using human genomics, AI and fly disease modelling to study the relationship between sleep and Alzheimer’s disease
Project Code NMH27Br Hodge Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary With ageing your 24-hour clock (circadian rhythms) and sleep get weaker. These symptoms are more pronounced in Alzheimer’s with poor rhythms and…
Mental health through the menopause transition
Project Code NMH27Br Joinson Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary The menopause transition is a period of increased risk of mental health problems, but there is poor understanding of which women are…
Linking neuronal function to mental health: How genetic risk factors impair cognitive flexibility and neural plasticity in schizophrenia
Project Code NMH27Br Mellor Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Genetic risk factors for schizophrenia are clustered around genes that regulate synaptic function and adaptation, pointing to underlying biological processes whose disruption…