Project Code IIAR27Br Laabei Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Complement is an ancient, conserved system vital for defence against pathogens and maintaining tissue homeostasis. However, dysregulation can cause damage contributing…
Hidden codes: Genetic Determinants of HIV-1 Fitness and Immune Recognition
Project Code IIAR27Br Mann Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary This project addresses the ongoing challenge posed by HIV-1, a virus infecting approximately 38 million people globally, with Subtype C (CHIV)…
Deciphering Intramolecular Communication Networks to Identify New Antibiotic Targets in Multidrug-Resistant Bacteria
Project Code IIAR27Br Oliveira Project Type Other Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Bacteria are becoming resistant to many of our most important antibiotics, creating an urgent need for new treatments. This project will investigate…
Understanding beta-lactam antibiotic targets to improve melioidosis treatment
Project Code IIAR27Br Spencer Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Melioidosis, caused by the bacterium Burkholderia pseudomallei, is a severe, frequently fatal, tropical disease. Beta-lactam antibiotics are cornerstones of melioidosis treatment,…
Overcoming β-lactamase-mediated antibiotic resistance by combining biomolecular simulation and experiment
Project Code IIAR27Br Van der Kamp Project Type Other Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Antibiotic resistance threatens human health. β-lactamases cause resistance to β-lactams, the most widely used antibiotics. Class C β- lactamases are…
You snooze, you win: harnessing hibernation biology for organ protection
Project Code NMH27Br Ambler Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Hibernating animals survive with barely-beating hearts and minimal oxygen. What if we could borrow that trick for critically ill patients? We’ve found…
Uncovering interneuron dysfunction in a mouse model of schizophrenia
Project Code NMH27Br Anastasiades Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary This project seeks to understand how disease-causing mutations linked to neurodevelopmental disorders, such as schizophrenia, alter cell types in the brain. The…
Can Virtual Reality (VR) embodiment experiences be used as part of treatment for eating disorders?
Project Code NMH27Br Bould Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Current treatments for eating disorders work for less than half of those affected, so it is vital to develop novel treatments. Virtual…
Cerebellar orchestration of social behaviour
Project Code NMH27Br Cahill Project Type Other Research Theme Neuroscience and Mental Health Project Summary Download Summary The cerebellum is increasingly recognised to contribute to behavioural flexibility and social cognition. Cerebellar changes are also a major risk factor for developing…
Decoding Early Brain and Movement Signals to Predict Outcomes after Birth Asphyxia
Project Code NMH27Br Chakkarapani Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Birth asphyxia occurs when a baby is deprived of oxygen around birth, causing brain injury, disability or death. This project will study…