Project Code
IIAR27Ca Ladell
Project Type
Wet lab
Research Theme
Infection, Immunity, and Antimicrobial Resistance
Project Summary Download
Summary
The risk of dying from infection is particularly high in the elderly and is related to ageing of the immune system. Immune cells called T-cells can confer long-term protection against infection and hence are critical for vaccine development. However, T-cell responses to infection become less effective with age, but the reasons for this are not yet well understood. You will examine T-cell dynamics using engineered protein technology, sophisticated imaging platforms (e.g., a FACSDiscover S8 with CellViewTM), molecular techniques (transcriptomics and telomere length assays), and bioinformatics to gain a better understanding of immune ageing to inform future vaccine design and immunotherapies.
Can the project be completed part time?
Yes
Lead Supervisor
Dr Kristin Ladell
Lead Supervisor Email
University Affiliation
Cardiff University
