Project Code IIAR27Br Laabei Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Complement is an ancient, conserved system vital for defence against pathogens and maintaining tissue homeostasis. However, dysregulation can cause damage contributing…
Hidden codes: Genetic Determinants of HIV-1 Fitness and Immune Recognition
Project Code IIAR27Br Mann Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary This project addresses the ongoing challenge posed by HIV-1, a virus infecting approximately 38 million people globally, with Subtype C (CHIV)…
Deciphering Intramolecular Communication Networks to Identify New Antibiotic Targets in Multidrug-Resistant Bacteria
Project Code IIAR27Br Oliveira Project Type Other Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Bacteria are becoming resistant to many of our most important antibiotics, creating an urgent need for new treatments. This project will investigate…
Understanding beta-lactam antibiotic targets to improve melioidosis treatment
Project Code IIAR27Br Spencer Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Melioidosis, caused by the bacterium Burkholderia pseudomallei, is a severe, frequently fatal, tropical disease. Beta-lactam antibiotics are cornerstones of melioidosis treatment,…
Overcoming β-lactamase-mediated antibiotic resistance by combining biomolecular simulation and experiment
Project Code IIAR27Br Van der Kamp Project Type Other Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Antibiotic resistance threatens human health. β-lactamases cause resistance to β-lactams, the most widely used antibiotics. Class C β- lactamases are…
Investigation of human cytomegalovirus modulation of gamma delta T cells
Project Code IIAR27Ca Fielding Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Immune cells are important for the control of viral infections. In particular, innate cytotoxic lymphocytes such as gamma delta T-cells and…
Understanding cellular ageing of protective immunity to inform vaccine design and T-cell therapies
Project Code IIAR27Ca Ladell Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary The risk of dying from infection is particularly high in the elderly and is related to ageing of the immune system.…
Immune modulation of tonsillar Natural Killer cell immunity by Group A Streptococcus
Project Code IIAR27Ca McLaren Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary The human tonsils are crucial for producing neutralizing antibodies against infection yet are a breeding ground for Group A Streptococcus (GAS)…
Receptor to Remedy: Rewiring adenovirus-host protein dynamics to engineer next-generation nanomedicines
Project Code IIAR27Ca Parker Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary How do viruses hijack our cells, and how can we turn this process to our advantage? This project will explore the…
Sweet disposition: combatting bacterial infections and antimicrobial resistance with designer proteins that target biofilm matrix carbohydrates
Project Code IIAR27Ca Parmeggiani Project Type Other Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Microorganisms grow as biofilms on surfaces, from teeth to surgical implants to the lining of lungs. Biofilms are dense cell aggregates embedded…